Blood Group Distribution and Its Association with Bleeding Time and Clotting Time Among Shalamar Medical Students
DOI:
https://doi.org/10.69591/jcihs.4.1.1Keywords:
ABO blood groups , bleeding time, clotting time, von Willebrand factorAbstract
Background:
ABO blood group have been associated with variability in hemostasis, largely due to differeces in plasma factor VIII levels and von Willebrand factor (vWF). These vatriations may influence bleeding tendency, bleeding severity and basic hemostatic parameters, clotting time (CT) and bleeding time (BT). Recent studies investigated the relationship across healthy populations and individuals with unexplained bleeding.
Objectives:
To ascertain whether ABO blood groups was influenced by hemostatic parameters like clotting time, vWF levels, bleeding time and bleeding severity.
Methods:
A cross-sectional study assessed relationship between basic coagulation markers, bleeding propensity, vWF variation and ABO blood groups.
Results:
Results showed differences between study populations. Blood group O individuals frequently had lower vWF levels, which can worsen bleeding in clinical cohorts. Some studies reported that in group O, BT and CT are slightly prolonged as compared to groups other than O, whereas other investigations showed no significant association between ABO types and hemostatic parameters in healthy individuals. Differences in study design, population characteristics, and sample size contributed to inconsistent results.
Conclusion:
ABO blood group may influence bleeding risk and hemostatic function, particularly in individuals with unexplained bleeding tendencies. However, variability in findings across studies indicated the need for standardized, larger-scale research to better clarify the clinical significance of ABO-related hemostatic differences.
References
1. Yameny AA. Prevalence of ABO and Rh blood groups in Alexandria city, Egypt. Journal of Medical and Life Science. 2021;3(3):44-8.
2. Yamamoto F. A historical overview of advances in molecular genetic/genomic studies of the ABO blood group system. Glycoconjugate Journal. 2022;39(2):207-18.
3. Daniels G. An overview of blood group genotyping. Annals of blood. 2023;8.
4. Tomc J, Debeljak N. Molecular insights into the oxygen-sensing pathway and erythropoietin expression regulation in erythropoiesis. International journal of molecular sciences. 2021;22(13):7074.
5. Rahman B, Ali G, Ullah Z, Uddin N, Ahmad N, Ahmad A. Frequency of ABO and Rhesus (Rh D) blood group in Pakistan. Pakistan Journal of Medical & Cardiological Review. 2025;4(3):1858-68.
6. Mengiste T. PHENOTYPIC AND GENOTYPIC FREQUENCIES OF ABO AND RH (D) BLOOD GROUPS AMONG STUDENTS IN MODJO SECONDARY SCHOOL, OROMIA, ETHIOPIA: Haramaya University; 2023.
7. McMichael MA. Overview of hemostasis. Schalm's Veterinary Hematology. 2022:763-86.
8. Bain BJ, Leach M. Blood cells: a practical guide: John Wiley & Sons; 2025.
9. Favaloro EJ, Pasalic L, Lippi G. Unfractionated heparin: optimizing laboratory monitoring and reducing unwanted interference in everyday hemostasis test practice. Polish Archives of Internal Medicine. 2024;134(3):1-9.
10. Montgomery RR, Flood VH, Haberichter SL. Von Willebrand factor structure and function. Textbook of von Willebrand disease: basic and clinical aspects. 2024:23-38.
11. Ward SE, O’Sullivan JM, O’Donnell JS. The relationship between ABO blood group, von Willebrand factor, and primary hemostasis. Blood, The Journal of the American Society of Hematology. 2020;136(25):2864-74.
12. Franchini M, Coppola A, Santoro C, De Cristofaro R, Barillari G, Giordano P, et al., editors. ABO blood group and inhibitor risk in severe hemophilia A patients: a study from the Italian Association of Hemophilia Centers. Seminars in Thrombosis and Hemostasis; 2021: Thieme Medical Publishers, Inc.
13. Petrou E, Donta AM, Mellou S, Tsalas S, Tsantes AG, Bethanis DA, et al., editors. The ABO blood system and associated implications for hemostasis and thrombosis. Seminars in Thrombosis and Hemostasis; 2025: Thieme Medical Publishers, Inc.
14. Bawazir WM. Systematic review and meta-analysis of the susceptibility of ABO blood groups to venous thromboembolism in individuals with factor V Leiden. Diagnostics. 2022;12(8):1936.
15. Adhikari B, Maharjan N. Blood group distribution and its association with bleeding time and clotting time among medical students. Asian Journal of Medical Sciences. 2024;15(8):151-5.
16. Weyand AC, Flood VH. Von Willebrand disease: current status of diagnosis and management. Hematology/oncology clinics of North America. 2021;35(6):1085.
17. Mehic D, Hofer S, Jungbauer C, Kaider A, Haslacher H, Eigenbauer E, et al. Association of ABO blood group with bleeding severity in patients with bleeding of unknown cause. Blood advances. 2020;4(20):5157-64.
18. Chinara A, Purohit P, Mahapatra B. No association of bleeding time and clotting time with four ABO blood groups in healthy young adults: An observational study. National Journal of Physiology, Pharmacy and Pharmacology. 2019;9(12):1193-.
19. Manandhar SA, Amatya M. Variation of bleeding time and clotting time in the ABO blood groups. Journal of Physiological Society of Nepal. 2020;1(2):19-23.
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Copyright (c) 2026 Tayyaba Saleem, Ayesha Saleem, Bushra Munir, Mariam Kamran, Ayesha Javid
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