Impact of ABO and Rh Blood Groups on Hepatitis B surface antigen reactivity amoung screened Blood Donors at Shalamar Hospital
DOI:
https://doi.org/10.69591/jcihs.3.2.1Keywords:
Hepatitis B virus, HBsAg, Blood Donors, ABO blood groups , Seroprevalence, , CMIAAbstract
Background: Hepatitis B virus (HBV) infection remains a significant global health concern, mainly among blood donors who play a vital role in preserving safe and adequate blood supplies. Blood donors serve as a key population for observing transfusion-transmissible infections, as screening their samples not only ensures patient safety but also provides insight into disease prevalence in the community. Regular HBsAg screening is therefore essential to safeguard both recipients and donors.
Objective: To determine the impact of HBsAg reactivity among blood donors and its association with ABO blood groups at the Blood Bank of Shalamar Hospital.
Methods: This cross-sectional descriptive study was conducted at the Blood Bank of Shalamar Hospital. A convenient sampling technique was used to include donors aged 18–60 years. ABO and Rh blood grouping were performed using both slide and tube agglutination methods. Screening for HBsAg was done on the ARCHITECT i1000SR immunoassay analyzer using Chemiluminescent Microparticle Immunoassay (CMIA) technology. Data were analyzed to evaluate the relationship between ABO blood groups and HBsAg reactivity.
Results: HBsAg seropositivity was found to vary with both gender and blood group. Male donors exhibited higher HBsAg reactivity compared to females, suggesting a possible gender related difference in exposure to HBV infection. Among blood groups, individuals with group B Particularly B+ showed a greater susceptibility to HBV infection than other types.
Conclusion: The results indicate a possible association between HBsAg reactivity, gender, and ABO blood groups. These findings highlight the importance of regular HBsAg screening in blood donation programs to guarantee transfusion safety and to identify population-specific susceptibility patterns. Continuous monitoring and larger-scale studies are recommended to confirm these associations and better understand HBV prevalence among donor populations.
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Copyright (c) 2026 Mariam Kamran, Ayesha Javid, Bushra Munir, Tayyaba Saleem, Ayesha Saleem
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